Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 8/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | KLK1 | P06870 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | FES | P07332 | 2/20 | 0.48 |
| ▸ | ROS1 | P08922 | 2/20 | 0.48 |
| ▸ | FER | P16591 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346697 | 0.79 | ABL1 (0.50) | KLKB1ABL1F2KLK1KDR | |
| SCHEMBL10283341 | 0.78 | KDR (0.55) | KLKB1ABL1KLK1KDRFGFR1 | |
| SCHEMBL3400528 | 0.77 | KDR (0.57) | KLKB1ABL1KLK1KDRFGFR1 | |
| SCHEMBL29858603 | 0.77 | KDR (0.60) | ABL1KDRFGFR1CDK8MAP4K4 | |
| SCHEMBL91324 | 0.77 | KDR (0.60) | ABL1KDRFGFR1CDK8MAP4K4 | |
| SCHEMBL25090827 | 0.74 | KLKB1 (0.47) | KLKB1ABL1F2KLK1MASP2 | |
| SCHEMBL11990128 | 0.74 | KDR (0.66) | KLKB1ABL1KDRFGFR1CDK8 | |
| SCHEMBL14638748 | 0.74 | KDR (0.56) | ABL1KDRFGFR1CDK8MAP4K4 | |
| SCHEMBL3348784 | 0.74 | CDK8 (0.63) | ABL1KDRFGFR1CDK8MAP4K4 | |
| SCHEMBL5100708 | 0.74 | RIPK1 (0.54) | KLKB1ABL1KDRFGFR1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051672-A1 | AZAINDOLE DERIVATIVES | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051672-A1 | AZAINDOLE DERIVATIVES | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |