⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691447 | 1.00 | — | — | |
| SCHEMBL1541120 | 1.00 | — | — | |
| SCHEMBL28243 | 0.87 | TSHR (0.50) | — | |
| SCHEMBL5798041 | 0.81 | TSHR (0.40) | — | |
| SCHEMBL97737 | 0.80 | — | — | |
| SCHEMBL322745 | 0.80 | — | — | |
| SCHEMBL1505898 | 0.80 | — | — | |
| SCHEMBL5579278 | 0.78 | TSHR (0.42) | — | |
| SCHEMBL3676083 | 0.78 | TSHR (0.42) | — | |
| SCHEMBL10774743 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |
| US-20240116943-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2024-04-11 | — | — | US | disclosed |
| EP-4227308-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | Japan Tobacco Inc. (JP) | 2023-08-16 | — | — | EP | disclosed |
| US-11708319-B2 | Biphenyl amides with modified ether groups as HSP90 inhibitors and HSP70 inducers | UNIVERSITY OF KANSAS (US) | 2023-07-25 | — | — | US | disclosed |
| CN-116437927-A | Tetrahydrobenzodiazepine ketone compound and pharmaceutical application thereof | 日本烟草产业株式会社 | 2023-07-14 | — | — | CN | disclosed |
| US-11643417-B2 | Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2023-05-09 | — | — | US | disclosed |
| US-11643417-B2 | Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2023-05-09 | — | — | US | disclosed |
| US-20220162220-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2022-05-26 | — | — | US | disclosed |
| CN-100335457-C | 3,4-dihydroxy butyric ester of which 3 chiral hydroxyl group is protected, and its preparation method | UNIV SHANGHAI JIAOTONG (CN) | 2007-09-05 | — | — | CN | disclosed |
| CN-1876644-A | (4R-cis)-6-formyl-2,2-dimethyl-1,3- dioxane -4- tertiary butyl acetate synthesis method | ZHEJIANG DONGGANG PHARMACEUTIC (CN) | 2006-12-13 | — | — | CN | disclosed |
| CN-1762975-A | 3,4-dihydroxy butyric ester of which 3 chiral hydroxyl group is protected, and its preparation method | UNIV SHANGHAI JIAOTONG (CN) | 2006-04-26 | — | — | CN | disclosed |
| EP-1027343-B2 | PROCESS FOR THE PREPARATION OF HYDROXY SUBSTITUTED GAMMA BUTYROLACTONES | UNIV MICHIGAN STATE (US) | 2006-01-11 | — | — | EP | disclosed |
| CN-1166782-C | Continuous process for preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives | 三星精密化学株式会社 | 2004-09-15 | — | — | CN | disclosed |
| US-RE38324-E1 | 4-hydroxy methyl butyrolactone, 3-hydroxybutyrolactone, 1,2,4-butanetriol and 3,4-dihydroxybutyric acid-1-methyl ester from malic acid; esterification; reduction with lithium borohydride | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-11-18 | — | — | US | disclosed |
| EP-1027343-B1 | PROCESS FOR THE PREPARATION OF HYDROXY SUBSTITUTED GAMMA BUTYROLACTONES | UNIV MICHIGAN STATE (US) | 2002-12-04 | — | — | EP | disclosed |
| CN-1316011-A | Continuous process for preparing optically pure -3, 4-dihydroxybutyric acid derivatives | SAMSUNG FINE CHEMICALS CO LTD (KR) | 2001-10-03 | — | — | CN | disclosed |
| US-5808107-A | REDUCTION OF A OXYDIESTER WITH ALKALI METAL BOROHYDRIDE | BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 1998-09-15 | — | — | US | disclosed |
| EP-0244364-A2 | Preparation of olefinic compounds | SANDOZ AG (CH) | 1987-11-04 | — | — | EP | disclosed |