Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16374017 | 0.62 | ABL1 (0.46) | EPHX2KMT2AMEN1ATMABL1 | |
| SCHEMBL2172826 | 0.59 | EPHX2 (0.51) | EPHX2KDM4EMAPTEPHX1 | |
| SCHEMBL6289309 | 0.59 | MAPT (0.55) | EPHX2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL14916657 | 0.57 | EPHX2 (0.56) | EPHX2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL5536264 | 0.57 | EPHX1 (0.64) | EPHX2KMT2AMEN1ABL1BCR | |
| Hydrochloric Acid SCHEMBL31155662 | 0.57 | EPHX1 (0.47) | EPHX2KMT2AMEN1ATMMAPT | |
| SCHEMBL27912284 | 0.57 | MAPT (0.59) | EPHX2KMT2AMEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL411544 | 0.56 | EPHX1 (0.63) | EPHX2KMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL12175682 | 0.56 | CARM1 (0.51) | EPHX2ALDH1A1 | |
| SCHEMBL27268412 | 0.55 | MAPT (0.57) | EPHX2KMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150593-A1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana Farber Cancer Institute, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |