Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.57 |
| ▸ | BCR | P11274 | 19/20 | 0.57 |
| ▸ | ADK | P55263 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18696325 | 0.85 | ADORA1 (0.51) | ABL1BCR | |
| SCHEMBL23637142 | 0.85 | ADORA1 (0.51) | ABL1BCR | |
| SCHEMBL20925483 | 0.84 | ABL1 (0.55) | ABL1BCRADK | |
| SCHEMBL3397073 | 0.80 | ADK (0.73) | ABL1BCRADK | |
| SCHEMBL20925355 | 0.80 | ADK (0.73) | ABL1BCRADK | |
| SCHEMBL13821121 | 0.80 | ADK (0.73) | ABL1BCRADK | |
| SCHEMBL19681258 | 0.80 | ADK (0.73) | ABL1BCRADK | |
| SCHEMBL16609159 | 0.80 | ADK (0.73) | ABL1BCRADK | |
| SCHEMBL22524104 | 0.78 | PRMT5 (0.48) | ABL1ADK | |
| SCHEMBL13467412 | 0.77 | NR2F2 (0.55) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912973-A2 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2021-11-24 | — | — | EP | disclosed |
| EP-3536687-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2021-07-14 | — | — | EP | disclosed |
| EP-3536687-A1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana Farber Cancer Institute, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| EP-3150593-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2019-04-24 | — | — | EP | disclosed |
| EP-3150593-A1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana Farber Cancer Institute, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |