SCHEMBL18697357

SCHEMBL18697357

O=C(F)Oc1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CDK8 P49336 2/20 0.44
AR P10275 3/20 0.40
KMO O15229 2/20 0.40
HTR2A P28223 1/20 0.40
SLC6A4 P31645 1/20 0.40
KCNH2 Q12809 1/20 0.40
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
GRM4 Q14833 1/20 0.39
TAS1R3 Q7RTX0 2/20 0.38
TAS1R1 Q7RTX1 2/20 0.38
TAS1R2 Q8TE23 2/20 0.38
NOTUM Q6P988 1/20 0.38
KCNQ3 O43525 1/20 0.37
KCNQ2 O43526 1/20 0.37
KCNE1 P15382 1/20 0.37
KCNQ1 P51787 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17352175 0.89 CDK8 (0.44) CDK8ARKMOHTR2ASLC6A4
SCHEMBL17352128 0.89 CDK8 (0.44) CDK8ARKMOHTR2ASLC6A4
SCHEMBL3710923 0.86 KIF11 (0.51) CDK8ARKMOHTR2ASLC6A4
SCHEMBL17356406 0.86 CDK8 (0.42) CDK8ARKMOHTR2ASLC6A4
SCHEMBL17352150 0.86 MAOB (0.45) CDK8ARKMOHTR2ASLC6A4
SCHEMBL1893249 0.86 LMNA (0.44) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17352125 0.86 MAOB (0.45) CDK8ARKMOHTR2ASLC6A4
SCHEMBL17352167 0.84 MAPT (0.44) CDK8ARKMOHTR2ASLC6A4
SCHEMBL17356472 0.84 CDK8 (0.44) CDK8ARHTR2ASLC6A4KCNH2
SCHEMBL17356329 0.84 CDK8 (0.41) CDK8ARKMOHTR2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170194664-A1 NONAQUEOUS ELECTROLYTE AND ELECTRICITY STORING DEVICE IN WHICH SAME IS USED MU IONIC SOLUTIONS CORPORATION (JP) 2017-07-06 US disclosed
US-20170194664-A1 NONAQUEOUS ELECTROLYTE AND ELECTRICITY STORING DEVICE IN WHICH SAME IS USED MU IONIC SOLUTIONS CORPORATION (JP) 2017-07-06 US disclosed
EP-3151326-A1 NONAQUEOUS ELECTROLYTE AND ELECTRICITY-STORING DEVICE IN WHICH SAME IS USED Ube Industries, Ltd. (JP) 2017-04-05 EP disclosed