Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 13/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28143442 | 0.78 | ERN1 (0.42) | ERN1PIM1LMNAMAPTMEN1 | |
| SCHEMBL27659824 | 0.77 | ERN1 (0.67) | ERN1PIM1LMNAMAPTMEN1 | |
| SCHEMBL27819554 | 0.75 | ERN1 (0.46) | ERN1PIM1LMNAMAPT | |
| SCHEMBL27915781 | 0.75 | ERN1 (0.47) | ERN1PIM1 | |
| SCHEMBL15002702 | 0.73 | ERN1 (0.45) | ERN1PIM1LMNAMAPT | |
| SCHEMBL15236193 | 0.72 | TDP1 (0.33) | LMNAMAPTMEN1ALDH1A1POLB | |
| SCHEMBL13258301 | 0.72 | TDP1 (0.32) | ERN1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL18717054 | 0.72 | ESR2 (0.41) | ERN1PIM1LMNAMAPTMEN1 | |
| SCHEMBL18717044 | 0.69 | ERN1 (0.63) | ERN1 | |
| SCHEMBL18595116 | 0.69 | XDH (0.33) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9622988-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-04-18 | — | — | US | disclosed |
| US-9610257-B2 | Small molecule xanthine oxidase inhibitors and methods of use | BAYLOR COLLEGE OF MEDICINE (US) | 2017-04-04 | — | — | US | disclosed |