Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.81 |
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.81 |
| ▸ | MAOB | P27338 | 3/20 | 0.81 |
| ▸ | BACE1 | P56817 | 3/20 | 0.81 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.81 |
| ▸ | STAT3 | P40763 | 3/20 | 0.81 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.81 |
| ▸ | RELA | Q04206 | 3/20 | 0.81 |
| ▸ | MMP9 | P14780 | 3/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.81 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.81 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.81 |
| ▸ | MAOA | P21397 | 2/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.81 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.81 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27909929 | 1.00 | APP (0.81) | APPMAPTNFKB1CYP2D6MAOB | |
| SCHEMBL27927798 | 0.92 | HTR1A (0.77) | APPMAPTNFKB1CYP2D6MAOB | |
| Curcumin SCHEMBL20595223 | 0.91 | APP (0.80) | APPMAPTNFKB1CYP2D6MAOB | |
| Curcumin SCHEMBL30547548 | 0.91 | APP (0.80) | APPMAPTNFKB1CYP2D6MAOB | |
| SCHEMBL3859807 | 0.90 | APP (0.83) | APPMAPTNFKB1CYP2D6MAOB | |
| SCHEMBL3859809 | 0.90 | APP (0.83) | APPMAPTNFKB1CYP2D6MAOB | |
| SCHEMBL9519980 | 0.90 | NFE2L2 (0.77) | APPMAPTNFKB1CYP2D6MAOB | |
| SCHEMBL9519985 | 0.90 | NFE2L2 (0.77) | APPMAPTNFKB1CYP2D6MAOB | |
| Curcumin SCHEMBL8440 | 0.89 | APP (1.00) | APPMAPTNFKB1CYP2D6MAOB | |
| Curcumin SCHEMBL17629819 | 0.89 | APP (1.00) | APPMAPTNFKB1CYP2D6MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549581-A2 | COMPOUNDS WITH (1E, 6E)-1,7-BIS-(3,4-DIMETHOXYPHENYL)-4,4-DISSTITUTED-HEPA-1,6-DIENE-3,5-DIONE STRUCTURAL SCAFFOLD, THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF | Allianz Pharmascience Ltd (TW) | 2019-10-09 | — | — | EP | disclosed |
| EP-3150203-A1 | COMPOUNDS WITH (1E,6E)-1,7-BIS-(3,4- DIMETHOXYPHENYL)-4,4-DISSTITUTED-HEPA-1,6-DIENE-3,5-DI-ONE STRUCTURAL SCAFFOLD,THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF | Allianz Pharmascience Ltd (TW) | 2017-04-05 | — | — | EP | disclosed |