Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18699862 | 0.88 | USP30 (0.44) | USP30FGFR4HCRTR1HCRTR2TMPRSS4 | |
| SCHEMBL18699770 | 0.84 | WNT3A (0.41) | FGFR4 | |
| SCHEMBL18699697 | 0.81 | NLRP3 (0.41) | — | |
| SCHEMBL18699685 | 0.80 | GAA (0.49) | MEN1KMT2A | |
| SCHEMBL30071320 | 0.75 | USP30 (0.54) | USP30HCRTR1HCRTR2TMPRSS4MEN1 | |
| SCHEMBL18838871 | 0.75 | USP30 (0.54) | USP30HCRTR1HCRTR2TMPRSS4MEN1 | |
| SCHEMBL18838878 | 0.72 | SMN1; SMN2 (0.54) | USP30TMPRSS4MEN1KMT2A | |
| SCHEMBL21589400 | 0.70 | USP30 (0.54) | USP30HCRTR1HCRTR2TMPRSS4MEN1 | |
| SCHEMBL1428781 | 0.70 | USP30 (0.54) | USP30TMPRSS4MEN1KMT2APORCN | |
| SCHEMBL14774917 | 0.69 | EGFR (0.48) | USP30HCRTR1HCRTR2TMPRSS4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846801-B1 | PYRIDINE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2017-04-05 | — | — | EP | disclosed |