Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742213 | 0.91 | POLB (0.58) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL18742163 | 0.89 | POLB (0.70) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL11118906 | 0.84 | POLB (0.52) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL2094424 | 0.84 | POLB (0.72) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL29434710 | 0.84 | POLB (0.72) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL20454667 | 0.79 | ALDH1A1 (0.67) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL21393470 | 0.74 | POLB (0.41) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL12465541 | 0.73 | POLB (0.52) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31295740 | 0.73 | POLB (0.67) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL11293369 | 0.73 | POLB (0.43) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060488-A1 | NEW TRPA1 ANTAGONISTS | ALMIRALL, S.A. (ES) | 2017-04-13 | — | — | WO | disclosed |