Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742213 | 0.81 | POLB (0.58) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL18704142 | 0.74 | POLB (0.57) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL26093940 | 0.72 | KDM4E (0.45) | POLBALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL23860779 | 0.71 | NOS3 (0.38) | ALDH1A1SMN1; SMN2MAPK1KMT2AKDM4E | |
| SCHEMBL30689574 | 0.71 | NOS3 (0.38) | ALDH1A1SMN1; SMN2MAPK1KMT2AKDM4E | |
| SCHEMBL15819694 | 0.71 | CYP3A4 (0.40) | POLBALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL23797868 | 0.70 | TERT (0.40) | ALDH1A1MAPK1KMT2AKDM4ECYP3A4 | |
| SCHEMBL29434710 | 0.69 | POLB (0.72) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL2094424 | 0.69 | POLB (0.72) | POLBALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL25337588 | 0.68 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |