Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 10/20 | 0.47 |
| ▸ | GRM5 | P41594 | 9/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18704507 | 0.79 | GPR119 (0.47) | HSD17B10GPR119MEN1KMT2AKDM4E | |
| SCHEMBL18694481 | 0.78 | KDM4E (0.47) | GRM1GRM5PDK4HSD17B10HTR6 | |
| SCHEMBL18704492 | 0.76 | GRM1 (0.49) | GRM1GRM5PDK4TNK2 | |
| SCHEMBL20217955 | 0.70 | GRM1 (0.56) | GRM1GRM5PDK4NAMPTTNK2 | |
| SCHEMBL2893158 | 0.70 | GRM1 (0.69) | GRM1GRM5PDK4NAMPTTNK2 | |
| SCHEMBL2893091 | 0.69 | GRM1 (0.61) | GRM1GRM5PDK4NAMPTTNK2 | |
| SCHEMBL18704441 | 0.69 | CFTR (0.47) | HSD17B10KDM4EHPGD | |
| SCHEMBL2239831 | 0.69 | NAMPT (0.66) | GRM1GRM5PDK4NAMPTTNK2 | |
| SCHEMBL23505457 | 0.69 | GRM1 (0.55) | GRM1GRM5PDK4NAMPTTNK2 | |
| SCHEMBL8613189 | 0.69 | GRM1 (0.62) | GRM1GRM5PDK4NAMPTTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060873-A1 | SUBSTITUTED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIC ACIDS AND THEIR USE | AbbVie S.à.r.l. (LU) | 2017-04-13 | — | — | WO | disclosed |