Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31721176 | 0.78 | KDM4E (0.46) | RAB9AKMT2ANPC1KDM4EALOX15 | |
| SCHEMBL2022195 | 0.78 | KDM4E (0.46) | RAB9AKMT2ANPC1KDM4EALOX15 | |
| SCHEMBL31721178 | 0.78 | KDM4E (0.46) | RAB9AKMT2ANPC1KDM4EALOX15 | |
| SCHEMBL15347911 | 0.76 | POLB (1.00) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL1131467 | 0.76 | SMN1; SMN2 (1.00) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL7022585 | 0.74 | KDM4E (0.64) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL160553 | 0.73 | GRK2 (0.47) | KMT2AKDM4ECDK2L3MBTL1ALDH1A1 | |
| SCHEMBL29773134 | 0.73 | GRK2 (0.47) | KMT2AKDM4ECDK2L3MBTL1ALDH1A1 | |
| SCHEMBL13201008 | 0.73 | RAB9A (0.70) | RAB9ASMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL30761113 | 0.72 | POLB (0.77) | RAB9ASMN1; SMN2NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060874-A1 | N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | ABBVIE S.Á.R.L (LU) | 2017-04-13 | — | — | WO | claimed |
| WO-2017060874-A1 | N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | ABBVIE S.Á.R.L (LU) | 2017-04-13 | — | — | WO | disclosed |