Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228000 | 0.91 | LMNA (0.80) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL2216711 | 0.91 | LMNA (0.80) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL18706418 | 0.88 | ALDH1A1 (0.74) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL18706397 | 0.85 | SMYD3 (1.00) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL18705832 | 0.85 | MAPT (0.62) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL20769036 | 0.85 | SMYD3 (0.75) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL20768830 | 0.85 | SMYD3 (0.75) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL18705892 | 0.85 | SMYD3 (0.75) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL18706517 | 0.85 | MAPT (0.71) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL18706141 | 0.85 | MAPT (0.65) | MAPTKMT2ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371151-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | Agency For Science, Technology And Research (SG) | 2018-09-12 | — | — | EP | disclosed |
| CN-108419435-A | Compound and epigenetics for treating cancer | 新加坡科技研究局 | 2018-08-17 | — | — | CN | disclosed |
| WO-2017061957-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-04-13 | — | — | WO | disclosed |