Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17236166 | 0.92 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL4652925 | 0.91 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL27519614 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL7377540 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL14907949 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL30592065 | 0.80 | NPC1 (0.71) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL18254456 | 0.80 | NPC1 (0.71) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL17336774 | 0.80 | KDM4E (0.64) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL31305679 | 0.80 | KDM4E (0.64) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL17087710 | 0.80 | NPC1 (0.75) | SMN1; SMN2ALDH1A1MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-30 | — | — | US | disclosed |
| US-20180282349-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-10-04 | — | — | US | disclosed |
| WO-2017060854-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364256-B2 | Biaryl pyrazoles as NRF2 regulators | NFE2L2, KEAP1, NQO1 | SMN1; SMN2 4243/4885ALDH1A1 372/4885MAPT 2730/4885 |
| US-20180282349-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | NFE2L2, KEAP1, NQO1 | SMN1; SMN2 4243/4885ALDH1A1 372/4885MAPT 2730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.