Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636986 | 0.86 | SMYD2 (0.46) | HRH3SMYD2EHMT2EHMT1MAPT | |
| SCHEMBL16291811 | 0.83 | KDM5C (0.51) | HRH3SMYD2EHMT2EHMT1MAPT | |
| SCHEMBL15637693 | 0.82 | KDM2B (0.51) | HRH3SMYD2EHMT2EHMT1 | |
| SCHEMBL15636566 | 0.81 | KDM2B (0.49) | HRH3SMYD2EHMT2EHMT1 | |
| SCHEMBL15994294 | 0.75 | CYP3A4 (0.43) | HRH3SMYD2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL19574376 | 0.74 | SCN5A (0.42) | HRH3LMNACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL15995479 | 0.72 | ALDH1A1 (0.64) | HRH3LMNACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL16006928 | 0.70 | CYP3A4 (0.43) | HRH3CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL16303322 | 0.69 | HRH3 (0.38) | HRH3CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL17984992 | 0.69 | HRH3 (0.38) | HRH3CYP3A4CYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |