Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15015523 | 0.87 | MAPT (0.44) | ALDH1A1KMT2AMEN1MAP4K4L3MBTL1 | |
| SCHEMBL1328836 | 0.83 | MEN1 (0.46) | ALDH1A1KMT2AMEN1L3MBTL1HTT | |
| SCHEMBL1328805 | 0.83 | ADORA2A (0.42) | ALDH1A1KMT2AMEN1MAP4K4RAB9A | |
| SCHEMBL29361274 | 0.81 | CSF1R (0.50) | ALDH1A1RAB9ANPC1CSF1RCYP2D6 | |
| SCHEMBL19785487 | 0.81 | CSF1R (0.50) | ALDH1A1RAB9ANPC1CSF1RCYP2D6 | |
| SCHEMBL68083 | 0.80 | CCR4 (0.43) | KMT2AHTT | |
| SCHEMBL29364914 | 0.80 | CCR4 (0.43) | KMT2AHTT | |
| SCHEMBL23012573 | 0.73 | KDM4C (0.34) | MAPK1 | |
| SCHEMBL29507183 | 0.73 | KDM4C (0.34) | MAPK1 | |
| SCHEMBL3146853 | 0.73 | FYN (0.44) | ALDH1A1FYNDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493878-B1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-10-12 | — | — | EP | disclosed |
| US-8293750-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-23 | — | — | US | disclosed |
| US-8293750-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-23 | — | — | US | disclosed |
| US-8293750-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-23 | — | — | US | disclosed |
| EP-2493878-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| US-20120202824-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-08-09 | — | — | US | disclosed |
| US-20120202824-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-08-09 | — | — | US | disclosed |
| US-20120202824-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-08-09 | — | — | US | disclosed |
| US-8183371-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-22 | — | — | US | disclosed |
| US-8183371-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-22 | — | — | US | disclosed |
| US-8183371-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-22 | — | — | US | disclosed |
| US-20110105527-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
| WO-2011053696-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
| US-20110105527-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
| WO-2011053696-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
| US-20110105527-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202824-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | OPRD1, OPRK1, OPRL1 | ALDH1A1 1103/4885KMT2A 3143/4885MEN1 4841/4885 |
| US-20110105527-A1 | PYRAZINES AS DELTA OPIOID RECEPTOR MODULATORS | OPRD1, OPRK1, OPRL1 | ALDH1A1 1103/4885KMT2A 3143/4885MEN1 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.