Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708799 | 0.88 | HKDC1 (0.44) | PIK3CDCYP1A2RXFP1POLBPIK3CG | |
| SCHEMBL12943411 | 0.86 | PIK3CD (0.42) | PIK3CDCYP1A2RXFP1POLBPIK3CG | |
| SCHEMBL12943784 | 0.86 | PIK3CD (0.43) | PIK3CDNOTUMFAAHMGLLMETAP2 | |
| SCHEMBL16596148 | 0.85 | NOTUM (0.48) | PIK3CDNOTUMFAAHMGLLMETAP2 | |
| SCHEMBL16591320 | 0.81 | PIK3CD (0.40) | PIK3CDNOTUMFAAHMGLLMETAP2 | |
| SCHEMBL22237904 | 0.80 | PIK3CD (0.50) | PIK3CDPIK3CGCASR | |
| SCHEMBL14757708 | 0.79 | TGM2 (0.37) | PIK3CDCYP1A2MAPTPOLBPIK3CG | |
| SCHEMBL16689262 | 0.79 | PIK3CD (0.45) | PIK3CDNOTUMFAAHMGLLMETAP2 | |
| SCHEMBL14649148 | 0.79 | PIK3CD (0.45) | PIK3CDNOTUMFAAHMGLLMETAP2 | |
| SCHEMBL13781779 | 0.78 | PIK3CD (0.49) | PIK3CDCYP1A2PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3811974-A1 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS | Infinity Pharmaceuticals, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3441392-A1 | A PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION | Intellikine, LLC (US) | 2019-02-13 | — | — | EP | disclosed |
| EP-3150609-A1 | PROCESS FOR PREPARING CERTAIN CHEMICAL ENTITIES | Intellikine, LLC (US) | 2017-04-05 | — | — | EP | disclosed |