Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CPS1 | P31327 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19121284 | 0.81 | CSNK2A1 (0.39) | CSNK2A1LOXL2CES2CES1CPS1 | |
| SCHEMBL16590409 | 0.80 | CPS1 (0.39) | CSNK2A1LOXL2CES2CES1CPS1 | |
| SCHEMBL9726681 | 0.79 | CSNK2A1 (0.47) | CSNK2A1LOXL2CES2CES1CPS1 | |
| SCHEMBL9887746 | 0.78 | CES2 (0.42) | CES2CES1PDK2LMNAALDH1A1 | |
| SCHEMBL14466443 | 0.78 | NPC1 (0.50) | CSNK2A1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL18971050 | 0.78 | GAA (0.39) | CSNK2A1HDAC7MEN1KMT2ANFE2L2 | |
| SCHEMBL29688899 | 0.78 | KMT2A (0.46) | CSNK2A1LOXL2CES2CES1CPS1 | |
| SCHEMBL1226712 | 0.78 | KMT2A (0.46) | CSNK2A1LOXL2CES2CES1CPS1 | |
| SCHEMBL489010 | 0.78 | CSNK2A1 (0.61) | CSNK2A1LOXL2MEN1KMT2AALDH1A1 | |
| SCHEMBL19889490 | 0.77 | CSNK2A1 (0.41) | CSNK2A1HDAC7MEN1KMT2ANFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3693366-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | Gilead Sciences, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-2683693-B1 | RORGAMMAT INHIBITORS | MERCK SHARP & DOHME (US) | 2017-04-05 | — | — | EP | disclosed |