Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12551855 | 0.83 | ALDH1A1 (0.41) | POLBALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14370492 | 0.83 | KDM1A (0.47) | POLBCYP1A2KDM4ES1PR4HSP90AA1 | |
| SCHEMBL13862948 | 0.83 | POLB (0.41) | POLBALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL18716703 | 0.83 | POLB (0.41) | POLBALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL13064596 | 0.83 | POLB (0.45) | POLBALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL22787328 | 0.81 | MAPT (0.44) | POLBALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL7623371 | 0.81 | ALDH1A1 (0.41) | POLBALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8340504 | 0.81 | KDM4E (0.45) | KDM4EMAPTL3MBTL1HTR2AHTR2C | |
| SCHEMBL12658946 | 0.81 | CTRC (0.48) | HTR2AHTR2CDRD2CLCN2 | |
| SCHEMBL14339474 | 0.81 | KDM4E (0.50) | POLBALDH1A1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678017-B1 | ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-04-05 | — | — | EP | disclosed |