Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18719884 | 0.93 | MEN1 (0.63) | GAAHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL15031161 | 0.86 | GAA (0.66) | GAAHTTHTR1AADRA1DADRA1A | |
| SCHEMBL1696130 | 0.84 | AVPR2 (0.65) | GAAHTTHTR1AADRA1DADRA1A | |
| SCHEMBL5899199 | 0.84 | GAA (0.66) | GAAHTTHTR1AADRA1DADRA1A | |
| SCHEMBL1690106 | 0.83 | GAA (0.62) | GAAHTTHTR1AADRA1DADRA1A | |
| SCHEMBL18970411 | 0.81 | HTT (0.59) | GAAHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL18773860 | 0.79 | KMT2A (0.72) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL15031151 | 0.79 | MEN1 (0.71) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL1696893 | 0.77 | AVPR2 (0.72) | GAAHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL5899205 | 0.77 | HTR1A (0.65) | GAAHTTHTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617224-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-04-11 | — | — | US | disclosed |