Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15031161 | 0.87 | GAA (0.66) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL5803986 | 0.85 | HPGD (0.70) | HPGDALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL1696130 | 0.85 | AVPR2 (0.65) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL18719367 | 0.84 | GAA (0.62) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL1690106 | 0.84 | GAA (0.62) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL5784422 | 0.83 | TP53 (0.63) | HPGDALDH1A1LMNA | |
| SCHEMBL5899203 | 0.81 | DRD4 (0.52) | GAAHTTALDH1A1KMT2ANPC1 | |
| SCHEMBL5899205 | 0.80 | HTR1A (0.65) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL31556814 | 0.80 | HPGD (1.00) | GAAHTTHPGDALDH1A1KMT2A | |
| SCHEMBL5783412 | 0.80 | HPGD (1.00) | GAAHTTHPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183902-A1 | Dihydroindolyl methanones as alpha 1a/1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-08-17 | — | — | US | disclosed |
| EP-0746556-B1 | TRICYCLIC COMPOUNDS HAVING AFFINITY FOR THE 5-HT1A RECEPTOR | ORTHO PHARMA CORP (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-0746556-A1 | TRICYCLIC COMPOUNDS HAVING AFFINITY FOR THE 5-HT1A RECEPTOR | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5512566-A | USEFUL IN TREATING DISEASES OF CENTRAL NERVOUS SYSTEM | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1995011903-A1 | TRICYCLIC COMPOUNDS HAVING AFFINITY FOR THE 5-HT1A RECEPTOR | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183902-A1 | Dihydroindolyl methanones as alpha 1a/1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms | ADRA1D, ADRA1A, ADRB1 | GAA 2945/4885HTT 3584/4885HPGD 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.