Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 4/20 | 0.78 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410621 | 0.88 | TSPO (0.77) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL406252 | 0.88 | TSPO (0.77) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL410057 | 0.88 | TSPO (1.00) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL18806386 | 0.88 | TSPO (1.00) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL409699 | 0.88 | TSPO (0.77) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL410188 | 0.88 | TSPO (1.00) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL409626 | 0.88 | TSPO (1.00) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL10287450 | 0.88 | TSPO (1.00) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL407526 | 0.88 | TSPO (0.77) | TSPODNM1CYP1A2CYP2C19OPRM1 | |
| SCHEMBL411251 | 0.84 | TSPO (0.71) | TSPODNM1MAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183011-B2 | Anti-depression compounds | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-01-22 | — | — | US | disclosed |
| US-20180127367-A1 | Pro-Neurogenic Compounds | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2018-05-10 | — | — | US | disclosed |
| US-9962368-B2 | Pro-neurogenic compounds | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-05-08 | — | — | US | disclosed |
| US-9884820-B2 | Pro-neurogenic compounds | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-02-06 | — | — | US | disclosed |
| US-20170157092-A1 | Anti-depression Compounds | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-08 | — | — | US | disclosed |
| US-9616048-B2 | Anti-depression compounds | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127367-A1 | Pro-Neurogenic Compounds | BDNF, GAP43, DCX | TSPO 2470/4885DNM1 897/4885CYP1A2 4486/4885 |
| US-10183011-B2 | Anti-depression compounds | BDNF, DCX, GAP43 | TSPO 2600/4885DNM1 638/4885CYP1A2 4439/4885 |
| US-20170157092-A1 | Anti-depression Compounds | BDNF, DCX, GAP43 | TSPO 2600/4885DNM1 638/4885CYP1A2 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.