Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18723941 | 1.00 | TAAR1 (0.38) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL18723576 | 0.95 | TAAR1 (0.38) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL2038237 | 0.90 | ADRA2A (0.43) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL18723819 | 0.84 | ADRA2A (0.35) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL18723575 | 0.76 | TAAR1 (0.33) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL18723601 | 0.75 | HTR6 (0.39) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL14903721 | 0.74 | TAAR1 (0.55) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL14903724 | 0.74 | TAAR1 (0.55) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL14903751 | 0.74 | TAAR1 (0.55) | TAAR1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL18723799 | 0.72 | TAAR1 (0.57) | TAAR1HTR1ADRD2HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507245-B1 | MULTICYCLIC COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2017-04-12 | — | — | EP | disclosed |