Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28306066 | 0.78 | ERN1 (0.39) | ERN1ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL19422197 | 0.76 | — | — | |
| SCHEMBL20689553 | 0.73 | MKNK1 (0.32) | ERN1 | |
| SCHEMBL19479788 | 0.71 | — | — | |
| SCHEMBL18878173 | 0.69 | HDAC6 (0.32) | — | |
| SCHEMBL13335303 | 0.69 | ADRA2A (0.36) | ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL20063344 | 0.69 | ALOX5AP (0.35) | ERN1BRD4 | |
| SCHEMBL16708773 | 0.68 | OPRM1 (0.41) | ERN1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13896967 | 0.67 | SMN1; SMN2 (0.38) | ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL165455 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47493-E1 | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-07-09 | — | — | US | disclosed |
| EP-2964617-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2017-04-12 | — | — | EP | disclosed |