Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221792 | 0.88 | POLB (0.39) | POLBALDH1A1HDAC1HDAC2HDAC4 | |
| SCHEMBL5499529 | 0.80 | ALDH1A1 (0.39) | POLBALDH1A1HDAC1HDAC2HDAC4 | |
| SCHEMBL13221627 | 0.80 | ALDH1A1 (0.38) | POLBALDH1A1HDAC1HDAC2HDAC4 | |
| SCHEMBL5485914 | 0.77 | ALDH1A1 (0.36) | POLBALDH1A1HDAC1HDAC2HDAC4 | |
| SCHEMBL30367749 | 0.77 | ALDH1A1 (0.36) | POLBALDH1A1HDAC1HDAC2HDAC4 | |
| SCHEMBL29352062 | 0.76 | ALDH1A1 (0.44) | ALDH1A1HDAC1HDAC2 | |
| SCHEMBL42368 | 0.76 | ALDH1A1 (0.44) | ALDH1A1HDAC1HDAC2 | |
| SCHEMBL12533282 | 0.74 | ALDH1A1 (0.40) | ALDH1A1HDAC1HDAC2 | |
| SCHEMBL13252991 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HDAC1HDAC2 | |
| SCHEMBL10340343 | 0.73 | ALDH1A1 (0.45) | POLBALDH1A1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4147046-A1 | HIGH IONIC STRENGTH DISSOCIATION ASSAY FOR HIGH DRUG TOLERANT TESTING | F. Hoffmann-La Roche AG (CH) | 2023-03-15 | — | — | EP | disclosed |
| WO-2021224360-A1 | HIGH IONIC STRENGTH DISSOCIATION ASSAY FOR HIGH DRUG TOLERANT TESTING | F. HOFFMANN-LA ROCHE AG (CH) | 2021-11-11 | — | — | WO | disclosed |
| WO-2021136772-A1 | METHOD FOR DETERMINING THE AMOUNT OF A THERAPEUTIC ANTIBODY IN THE BRAIN | F. HOFFMANN-LA ROCHE AG (CH) | 2021-07-08 | — | — | WO | disclosed |
| EP-3156418-A1 | ANTI-EPHB4 ANTIBODIES AND METHODS USING SAME | Genentech, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |