SCHEMBL187254

SCHEMBL187254

Cc1nc(C#Cc2cccnc2)cs1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 17/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2D6 P10635 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30273059 1.00 GRM5 (1.00) GRM5CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL1803964 0.98 GRM5 (0.97) GRM5CYP1A2CYP2D6
SCHEMBL7425347 0.86 GRM5 (1.00) GRM5CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL7419836 0.85 GRM5 (0.97) GRM5CYP1A2CYP2D6
SCHEMBL11966024 0.83 GRM5 (0.70) GRM5CYP1A2CYP2D6
SCHEMBL11966077 0.83 GRM5 (0.70) GRM5CYP1A2CYP2D6
SCHEMBL5653485 0.83 GRM5 (1.00) GRM5CYP1A2CYP2D6
SCHEMBL4158461 0.83 GRM5 (1.00) GRM5CYP1A2CYP2D6
SCHEMBL3458329 0.82 GRM5 (1.00) GRM5CYP1A2CYP2D6
SCHEMBL11966074 0.82 GRM5 (0.68) GRM5CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 382 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124188-A1 mGluR receptor antagonists for use in prevention andor treatment of bone marrow lesions (BML) andor osteoporosis, cartilage loss, osteosclerosis and osteitis in a mammal ORPHELION AB (SE) 2026-05-07 US claimed
EP-4583872-A1 MGLUR5 RECEPTOR ANTAGONISTS FOR USE IN PREVENTION AND/OR TREATMENT OF BONE MARROW LESIONS (BML) AND/OR OSTEOPOROSIS, CARTILAGE LOSS, OSTEOSCLEROSIS, OSTEITIS IN A MAMMAL ORPHELION AB (SE) 2025-07-16 EP claimed
US-20240408090-A1 Methods Of Treating Dyskinesia And Related Disorders MELIOR PHARMACEUTICALS II, LLC 2024-12-12 US claimed
US-12048697-B2 Methods of treating dyskinesia and related disorders MELIOR PHARMACEUTICALS II, LLC (US) 2024-07-30 US claimed
WO-2024088712-A1 MGLUR5 RECEPTOR ANTAGONISTS FOR USE IN PREVENTION AND/OR TREATMENT OF BONE MARROW LESIONS (BML) AND/OR OSTEOPOROSIS, CARTILAGE LOSS, OSTEOSCLEROSIS, OSTEITIS IN A MAMMAL ORPHELION AB (SE) 2024-05-02 WO claimed
US-20220331320-A1 Methods Of Treating Dyskinesia And Related Disorders MELIOR PHARMACEUTICALS II, LLC 2022-10-20 US claimed
US-20190328736-A1 Methods Of Treating Dyskinesia And Related Disorders CAVALRY FUND I LP 2019-10-31 US claimed
EP-3160464-A1 USE OF BUSPIRONE METABOLITES Contera Pharma APS (DK) 2017-05-03 EP claimed
US-20160257957-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME AND AUTISM SPECTRUM DISORDERS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-09-08 US claimed
EP-2544688-B1 METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME HARVARD COLLEGE (US) 2016-09-07 EP claimed
US-20090192199-A1 PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-07-30 US claimed
WO-2009076529-A1 SMALL MOLECULES FOR NEURONAL DIFFERENTIATION OF EMBRYONIC STEM CELLS RESEARCH DEVELOPMENT FOUNDATION (US) 2009-06-18 WO claimed
EP-2010174-A2 PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION The Regents of the University of California (US) 2009-01-07 EP claimed
WO-2007124348-A2 PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-11-01 WO claimed
US-20070160850-A1 Fluoro-compound water repellent composition for wood product dimensional stability OSMOSE, INC. (US) 2007-07-12 US claimed
WO-2007067648-A2 FLUORO-COMPOUND WATER REPELLENT COMPOSITION FOR WOOD PRODUCT DIMENSIONAL STABILITY OSMOSE, INC. (US) 2007-06-14 WO claimed
JP-2006516587-A 2006-07-06 JP claimed
EP-1599204-A2 SELECTIVE MGLU5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT Recordati Ireland Limited (IE) 2005-11-30 EP claimed
US-20040215284-A1 Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists RECORDATI S.A. 2004-10-28 US claimed
WO-2004067002-A2 SELECTIVE mGlu5 ANTAGONISTS FOR TREATMENT OF NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT RECORDATI IRELAND LIMITED (IE) 2004-08-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220331320-A1 Methods Of Treating Dyskinesia And Related Disorders SLC6A3, CHAT, ACHE GRM5 319/4885CYP1A2 2019/4885CYP2D6 943/4885
US-20240408090-A1 Methods Of Treating Dyskinesia And Related Disorders SLC6A3, CHAT, ACHE GRM5 319/4885CYP1A2 2019/4885CYP2D6 943/4885
US-20260124188-A1 mGluR receptor antagonists for use in prevention andor treatment of bone marrow lesions (BML) andor osteoporosis, cartilage loss, osteosclerosis and osteitis in a mammal GRM5, OPRL1, GRM1 GRM5 1/4885CYP1A2 4061/4885CYP2D6 3131/4885
US-20090192199-A1 PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION GRM1, GRM2, GRIN1 GRM5 13/4885CYP1A2 4845/4885CYP2D6 4853/4885
US-12048697-B2 Methods of treating dyskinesia and related disorders SLC6A3, CHAT, ACHE GRM5 319/4885CYP1A2 2019/4885CYP2D6 943/4885
US-20190328736-A1 Methods Of Treating Dyskinesia And Related Disorders SLC6A3, CHAT, ACHE GRM5 319/4885CYP1A2 2019/4885CYP2D6 943/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.