Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 6/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | BUB1 | O43683 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18725955 | 0.90 | THRB (0.47) | TGFBR1TGFBR2MAP3K20THRBCSNK1D | |
| SCHEMBL18725988 | 0.87 | CSNK1D (0.36) | TGFBR1TGFBR2MAP3K20THRBGAK | |
| SCHEMBL18725978 | 0.85 | TGFBR1 (0.37) | TGFBR1TGFBR2MAP3K20THRBGAK | |
| SCHEMBL14844726 | 0.84 | GRM5 (0.42) | BUB1PTGER1 | |
| SCHEMBL2524463 | 0.81 | THRB (0.46) | TGFBR1TGFBR2MAP3K20THRBCSNK1D | |
| SCHEMBL18725969 | 0.80 | THRB (0.46) | TGFBR1TGFBR2MAP3K20THRBMAPK14 | |
| SCHEMBL18725951 | 0.80 | THRB (0.45) | TGFBR1TGFBR2MAP3K20THRBCSNK1D | |
| SCHEMBL14844937 | 0.78 | THRB (0.45) | TGFBR1TGFBR2THRBBUB1CSNK1D | |
| SCHEMBL18725977 | 0.77 | THRB (0.48) | TGFBR1TGFBR2MAP3K20THRBMAPK14 | |
| SCHEMBL18725974 | 0.76 | THRB (0.41) | TGFBR1TGFBR2MAP3K20THRBBUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763993-B1 | HETEROCYCLYLPYRI(MI)DINYLPYRAZOLE | BAYER IP GMBH (DE) | 2017-04-19 | — | — | EP | disclosed |