Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581610 | 0.81 | CHRM2 (0.42) | SMN1; SMN2RETGPR119USP2 | |
| SCHEMBL27691226 | 0.79 | LMNA (0.44) | KMT2ASMN1; SMN2LMNAPKMALDH1A1 | |
| SCHEMBL1872078 | 0.74 | PANK3 (0.51) | HRH2HRH1KMT2ASMN1; SMN2KIT | |
| SCHEMBL1692682 | 0.72 | HRH2 (0.48) | HRH2HRH1KMT2ALMNAHRH3 | |
| SCHEMBL14922331 | 0.72 | HRH2 (0.54) | HRH2HRH1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL18482713 | 0.71 | HRH2 (0.47) | HRH2HRH1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3958428 | 0.71 | HRH2 (0.47) | HRH2HRH1KMT2ALMNAHRH3 | |
| SCHEMBL3632495 | 0.71 | HRH2 (0.47) | HRH2HRH1KMT2ALMNAHRH3 | |
| SCHEMBL24664442 | 0.70 | HRH2 (0.49) | HRH2HRH1KMT2AHRH3KIT | |
| SCHEMBL30939700 | 0.70 | GAA (0.41) | SMN1; SMN2LMNAPKMALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496557-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054841-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |