Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29741207 | 1.00 | MAOB (0.46) | MAOBMAOACYP2A6NOTUMTSHR | |
| SCHEMBL31686453 | 0.89 | NOTUM (0.47) | MAOBMAOACYP2A6NOTUMKDM4E | |
| SCHEMBL297461 | 0.89 | NOTUM (0.47) | MAOBMAOACYP2A6NOTUMKDM4E | |
| SCHEMBL5686077 | 0.89 | NOTUM (0.47) | MAOBMAOACYP2A6NOTUMKDM4E | |
| SCHEMBL11739357 | 0.84 | CYP2A6 (0.44) | MAOBMAOACYP2A6TSHRKDM4E | |
| SCHEMBL28041457 | 0.80 | MAOA (0.56) | MAOBMAOACYP2A6TSHRKDM4E | |
| SCHEMBL10913908 | 0.76 | CYP2A6 (0.44) | MAOBMAOACYP2A6NOTUMTSHR | |
| SCHEMBL4578838 | 0.76 | CYP11B1 (0.46) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL29740975 | 0.75 | MAOA (0.42) | MAOBMAOACYP2A6TSHRKDM4E | |
| SCHEMBL1151194 | 0.75 | PARP1 (0.55) | MAOBMAOACYP2A6TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022155419-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2022-07-21 | — | — | WO | disclosed |
| EP-2714675-B1 | 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2019-01-02 | — | — | EP | disclosed |
| EP-2714675-B1 | 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2019-01-02 | — | — | EP | disclosed |
| US-9624238-B2 | 4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-9624238-B2 | 4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-9624238-B2 | 4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-9394264-B2 | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394264-B2 | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394264-B2 | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| EP-2771005-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2016-05-18 | — | — | EP | disclosed |
| WO-2001046157-A1 | BENZO[A]PHENAZIN-11-CARBOXAMIDE DERIVATIVES AND THEIR USE AS JOINT INHIBITORS OF TOPOMERASE I AND II | XENOVA LIMITED (GB) | 2001-06-28 | — | — | WO | disclosed |
| US-5840911-A | ANTIPROTOZOA, ANTITUMOR | NOVARTIS AG (CH) | 1998-11-24 | — | — | US | disclosed |
| EP-0808309-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | Novartis AG (CH) | 1997-11-26 | — | — | EP | disclosed |
| US-5639911-A | Hydrazones | CIBA-GEIGY CORPORATION (US) | 1997-06-17 | — | — | US | disclosed |
| WO-1996022979-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | NOVARTIS AG (CH) | 1996-08-01 | — | — | WO | disclosed |
| US-5461076-A | Inhibitors of S-adenosylmethionine decarboxylase; antitumor agents | NOVARTIS CORPORATION | 1995-10-24 | — | — | US | disclosed |
| EP-0456133-B1 | Hydrazones | CIBA GEIGY AG (CH) | 1995-03-15 | — | — | EP | disclosed |
| US-5395855-A | Antitumor agents | CIBA-GEIGY CORPORATION (US) | 1995-03-07 | — | — | US | disclosed |
| EP-0538193-A2 | Condensed cycloaliphatir-amidino-hydrazon salts as S-adenosylmethionin decarboxylase inhibitors | CIBA-GEIGY AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0456133-A1 | Hydrazones | CIBA-GEIGY AG (CH) | 1991-11-13 | — | — | EP | disclosed |