Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1872985 | 0.92 | TPH1 (0.56) | TPH1 | |
| SCHEMBL27809408 | 0.87 | TPH1 (0.61) | TPH1 | |
| SCHEMBL1131296 | 0.87 | TPH1 (0.61) | TPH1 | |
| SCHEMBL1869997 | 0.87 | TPH1 (0.61) | TPH1 | |
| SCHEMBL1877770 | 0.85 | TPH1 (0.49) | TPH1 | |
| SCHEMBL1768159 | 0.85 | TPH1 (0.53) | TPH1 | |
| SCHEMBL1869970 | 0.85 | TPH1 (0.51) | TPH1 | |
| SCHEMBL1129387 | 0.83 | TPH1 (0.58) | TPH1 | |
| SCHEMBL1880942 | 0.79 | TPH1 (0.49) | TPH1 | |
| SCHEMBL1129122 | 0.79 | TPH1 (0.49) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496231-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF CANCER | Lexicon Pharmaceuticals, Inc. (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011056916-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-12 | — | — | WO | disclosed |