Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18736368 | 0.99 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30658879 | 0.99 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL26334788 | 0.95 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28362584 | 0.86 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6652205 | 0.83 | TDP1 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18736538 | 0.81 | TDP1 (0.64) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL22498785 | 0.80 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18736532 | 0.79 | TDP1 (0.45) | RAB9ASMN1; SMN2ALDH1A1LMNATDP1 | |
| SCHEMBL18736257 | 0.79 | TDP1 (0.64) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31354692 | 0.78 | LMNA (0.67) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060728-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | AVVINITY THERAPEUTICS LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |
| WO-2017060729-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | CENTAURI THERAPEUTICS LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |