Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1873796 | 0.79 | CKS1B (0.57) | SMN1; SMN2RETALDH1A1LMNATSHR | |
| SCHEMBL3652269 | 0.76 | PANK3 (0.58) | SMN1; SMN2HPGDRETPANK3KDM4E | |
| SCHEMBL1872078 | 0.75 | PANK3 (0.51) | SMN1; SMN2HPGDPANK3KITHRH2 | |
| SCHEMBL3532895 | 0.75 | KMT2A (0.45) | SMN1; SMN2HPGDRETHRH3KIT | |
| SCHEMBL3530997 | 0.75 | KIT (0.43) | SMN1; SMN2HPGDRETKITSMO | |
| SCHEMBL3531390 | 0.74 | TRPV1 (0.53) | KITSMOHRH1 | |
| SCHEMBL1877788 | 0.73 | PANK3 (0.58) | SMN1; SMN2PANK3KITALDH1A1LMNA | |
| SCHEMBL1879875 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDRETPANK3HRH3 | |
| SCHEMBL3799545 | 0.73 | MEN1 (0.47) | SMN1; SMN2HPGDHRH3KITHRH2 | |
| SCHEMBL14837557 | 0.72 | HRH3 (0.44) | SMN1; SMN2HPGDRETHRH3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496557-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054841-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |