Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31663109 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDHRH3USP30DGAT1 | |
| SCHEMBL16278211 | 0.84 | HDAC1 (0.53) | SMN1; SMN2HPGDHRH3DGAT1NR1H2 | |
| SCHEMBL23973426 | 0.83 | MAP4K4 (0.44) | SMN1; SMN2HPGDRETUSP30DGAT1 | |
| SCHEMBL182911 | 0.82 | USP30 (0.58) | SMN1; SMN2HPGDRETUSP30DGAT1 | |
| SCHEMBL30515664 | 0.82 | USP30 (0.58) | SMN1; SMN2HPGDRETUSP30DGAT1 | |
| SCHEMBL1390680 | 0.81 | ALDH1A1 (0.48) | HPGDRETUSP30DGAT1ALDH1A1 | |
| SCHEMBL29964577 | 0.81 | ALDH1A1 (0.48) | HPGDRETUSP30DGAT1ALDH1A1 | |
| SCHEMBL1292021 | 0.81 | USP30 (0.42) | SMN1; SMN2HPGDUSP30DGAT1KDM4E | |
| SCHEMBL31646023 | 0.81 | KDM4E (0.40) | SMN1; SMN2HPGDRETHRH3USP30 | |
| SCHEMBL1985044 | 0.78 | ALDH1A1 (0.41) | SMN1; SMN2HPGDKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496557-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054841-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |