Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 2/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15558806 | 1.00 | DYRK1B (0.34) | DYRK1BMAP2K1CLK4IRAK4PARP1 | |
| SCHEMBL31293979 | 0.84 | KDM4E (0.41) | KDM4EL3MBTL1 | |
| SCHEMBL2271909 | 0.71 | — | — | |
| SCHEMBL10635898 | 0.71 | — | — | |
| SCHEMBL31488319 | 0.66 | METAP2 (0.37) | PARP1KDM4E | |
| SCHEMBL1420264 | 0.64 | MKNK1 (0.47) | DYRK1BMAP2K1CLK4IRAK4PARP1 | |
| SCHEMBL2380423 | 0.64 | IRAK4 (0.51) | DYRK1BMAP2K1CLK4IRAK4PARP1 | |
| SCHEMBL11339171 | 0.63 | IRAK4 (0.41) | DYRK1BMAP2K1CLK4IRAK4PARP1 | |
| Hydrochloric Acid SCHEMBL30521486 | 0.63 | MKNK1 (0.46) | DYRK1BMAP2K1CLK4IRAK4PARP1 | |
| SCHEMBL15266367 | 0.63 | KDM5A (0.40) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883649-A1 | IMIDAZO-PYRAZOLE CARBOXAMIDE DERIVATIVES AS ANTICANCER AGENTS AND THE SYNTHESIS THEREOF | Avidin KFT (HU) | 2021-09-29 | — | — | EP | claimed |
| EP-3883649-A1 | IMIDAZO-PYRAZOLE CARBOXAMIDE DERIVATIVES AS ANTICANCER AGENTS AND THE SYNTHESIS THEREOF | Avidin KFT (HU) | 2021-09-29 | — | — | EP | disclosed |
| EP-3362454-A1 | EP4 ANTAGONISTS | Eisai R&D Management Co., Ltd. (JP) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017066633-A1 | EP4 ANTAGONISTS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-04-20 | — | — | WO | disclosed |