Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18740588 | 1.00 | KMT2A (0.41) | KMT2AMAPTTP53SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL28709662 | 0.98 | KMT2A (0.40) | KMT2AMAPTTP53SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL28709659 | 0.98 | KMT2A (0.40) | KMT2AMAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL18740496 | 0.84 | ALDH1A1 (0.41) | KMT2AMAPTMEN1ALDH1A1POLB | |
| SCHEMBL18740497 | 0.84 | ALDH1A1 (0.41) | KMT2AMAPTMEN1ALDH1A1POLB | |
| SCHEMBL7846754 | 0.84 | ALDH1A1 (0.42) | KMT2ASMN1; SMN2MEN1GAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL18740594 | 0.83 | ALDH1A1 (0.41) | KMT2AMAPTLMNAALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL18740595 | 0.83 | ALDH1A1 (0.41) | KMT2AMAPTLMNAALDH1A1POLB | |
| SCHEMBL18740499 | 0.81 | KMT2A (0.41) | KMT2AMAPTTP53SMN1; SMN2MEN1 | |
| SCHEMBL18763261 | 0.79 | KMT2A (0.40) | KMT2AMAPTTP53SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954225-B2 | Selective NR2B antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-03-23 | — | — | US | disclosed |
| EP-3362447-B1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-26 | — | — | EP | disclosed |
| US-20200115370-A1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-04-16 | — | — | US | disclosed |
| US-20180312495-A1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2018-11-01 | — | — | US | disclosed |
| EP-3362447-A1 | SELECTIVE NR2B ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017066368-A1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-04-20 | — | — | WO | disclosed |
| WO-2017066368-A1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115370-A1 | SELECTIVE NR2B ANTAGONISTS | GRIN2B, GRIN2A, GRIN1 | KMT2A 2099/4885MAPT 1275/4885TP53 4687/4885 |
| US-10954225-B2 | Selective NR2B antagonists | GRIN2B, GRIN2A, GRIN1 | KMT2A 2099/4885MAPT 1275/4885TP53 4687/4885 |
| US-20180312495-A1 | SELECTIVE NR2B ANTAGONISTS | GRIN2A, GRIN2B, GRIN1 | KMT2A 1992/4885MAPT 1373/4885TP53 4715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.