Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.33 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941211 | 0.87 | PIM1 (0.36) | PIM1TTKPIM2 | |
| SCHEMBL9941368 | 0.86 | SCN9A (0.40) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL9942368 | 0.85 | PIM1 (0.35) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL18752121 | 0.84 | PIM1 (0.34) | PIM1TTKPIM2 | |
| SCHEMBL10219356 | 0.84 | PLK1 (0.41) | AURKACCNA2CDK2CCNA1PLK1 | |
| SCHEMBL9940662 | 0.83 | AURKA (0.36) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL9940675 | 0.82 | PIM1 (0.43) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL9940573 | 0.77 | PLK1 (0.41) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL9940756 | 0.77 | AURKA (0.38) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL10220012 | 0.76 | CCNA2 (0.34) | PIM1TTKPIM2AURKACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-B1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-04-19 | — | — | EP | disclosed |