Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941211 | 0.96 | PIM1 (0.36) | PIM1TTKPIM2FGFR1 | |
| SCHEMBL10220012 | 0.92 | CCNA2 (0.34) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL9941368 | 0.86 | SCN9A (0.40) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL10219356 | 0.85 | PLK1 (0.41) | AURKACCNA2CDK2CCNA1PLK1 | |
| SCHEMBL18752120 | 0.85 | PIM1 (0.35) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL9940756 | 0.84 | AURKA (0.38) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL18752121 | 0.84 | PIM1 (0.34) | PIM1TTKPIM2 | |
| SCHEMBL9940662 | 0.83 | AURKA (0.36) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL15267961 | 0.83 | MEN1 (0.37) | PIM1TTKPIM2AURKACCNA2 | |
| SCHEMBL10215999 | 0.82 | AURKA (0.38) | PIM1TTKPIM2AURKACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012080990-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-21 | — | — | WO | disclosed |