Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18752408 | 1.00 | GPR119 (0.49) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL13724794 | 1.00 | GPR119 (0.49) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL13115713 | 0.90 | ADRA1A (0.53) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL19121425 | 0.90 | MAPT (0.59) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL10154595 | 0.86 | GRIN2D (0.49) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL15034211 | 0.83 | GPR119 (0.49) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL16260503 | 0.83 | GPR119 (0.49) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL16260556 | 0.83 | GPR119 (0.49) | GPR119MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL16472352 | 0.82 | GRIN2D (0.49) | GPR119GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL24655824 | 0.82 | PDE10A (0.52) | GPR119GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305778-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2018-04-11 | — | — | EP | disclosed |
| EP-2999697-B1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LTD (GB) | 2017-04-19 | — | — | EP | disclosed |