Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CPS1 | P31327 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753678 | 0.88 | LRRK2 (0.48) | LMNATSHRLRRK2 | |
| SCHEMBL18753852 | 0.87 | POLB (0.45) | TSHRLRRK2MAP3K7POLBCPS1 | |
| SCHEMBL18753787 | 0.86 | LRRK2 (0.49) | LMNATSHRLRRK2 | |
| SCHEMBL20750527 | 0.83 | KMT2A (0.55) | LMNALRRK2POLB | |
| SCHEMBL18753869 | 0.83 | MYC (0.49) | LMNALRRK2MAP3K7 | |
| SCHEMBL19562201 | 0.83 | TSHR (0.50) | LMNATSHRPOLBCPS1 | |
| SCHEMBL18753710 | 0.82 | CPS1 (0.46) | LMNATSHRPOLBCPS1 | |
| SCHEMBL20750678 | 0.82 | HPGD (0.48) | LMNATSHRLRRK2POLB | |
| SCHEMBL20750359 | 0.81 | ALDH1A1 (0.47) | LMNATSHRPOLB | |
| SCHEMBL18753860 | 0.80 | LRRK2 (0.45) | LMNALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241554-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-2448582-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2017-04-19 | — | — | EP | disclosed |