Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | BCR | P11274 | 3/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CPS1 | P31327 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753827 | 0.88 | LRRK2 (0.43) | MYCMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL22422552 | 0.87 | POLB (0.46) | POLBMYCMEN1KMT2AABL1 | |
| SCHEMBL18753335 | 0.87 | LMNA (0.47) | POLBLRRK2TSHRMAP3K7CPS1 | |
| SCHEMBL18753307 | 0.85 | TSHR (0.47) | POLBHPGDALDH1A1L3MBTL1TSHR | |
| SCHEMBL18753748 | 0.85 | RBP4 (0.47) | POLBMYCABL1BCRHPGD | |
| SCHEMBL18753487 | 0.85 | ALDH1A1 (0.54) | POLBKMT2AABL1BCRHPGD | |
| SCHEMBL18753811 | 0.83 | PKM (0.55) | POLBMYCMEN1KMT2AABL1 | |
| SCHEMBL20750502 | 0.82 | POLB (0.50) | POLBABL1BCRALDH1A1L3MBTL1 | |
| SCHEMBL18753318 | 0.82 | KMT2A (0.59) | POLBMEN1KMT2AABL1BCR | |
| SCHEMBL18753484 | 0.82 | MYC (0.54) | MYCMEN1KMT2AABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241554-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-2448582-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2017-04-19 | — | — | EP | disclosed |