Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PKLR | P30613 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21650911 | 0.96 | GRIN2B (0.48) | NPC1KDM4EALDH1A1PRKAA2PRKAB2 | |
| SCHEMBL18753736 | 0.94 | SMN1; SMN2 (0.48) | NPC1KDM4EALDH1A1PRKAA2PRKAB2 | |
| SCHEMBL18753314 | 0.92 | PKLR (0.51) | KDM4EALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL20192393 | 0.92 | PRKAA2 (0.51) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL18753474 | 0.92 | PKLR (0.51) | KDM4EALDH1A1MEN1KMT2APKLR | |
| SCHEMBL18754024 | 0.90 | ALDH1A1 (0.53) | NPC1KDM4EALDH1A1PRKAA2MEN1 | |
| SCHEMBL18753961 | 0.90 | PKLR (0.47) | KDM4EALDH1A1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL20192355 | 0.90 | PKLR (0.52) | KDM4EALDH1A1KMT2ATSHRL3MBTL1 | |
| SCHEMBL21650900 | 0.89 | LSS (0.48) | KDM4EALDH1A1KMT2ATSHRL3MBTL1 | |
| SCHEMBL18754032 | 0.89 | PKLR (0.46) | KDM4EALDH1A1PRKAA2PKLRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448582-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2017-04-19 | — | — | EP | disclosed |