Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18754289 | 0.86 | SPHK1 (0.38) | NPC1RAB9AHPGDTP53SMN1; SMN2 | |
| SCHEMBL20799635 | 0.74 | MEN1 (0.40) | NPC1RAB9AHPGDTP53SMN1; SMN2 | |
| SCHEMBL10306614 | 0.72 | S1PR1 (0.42) | KMT2AMEN1CYP2C19KDM4EALDH1A1 | |
| SCHEMBL11934948 | 0.72 | SIGMAR1 (0.53) | HPGDKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2014436 | 0.71 | S1PR1 (0.39) | KMT2AMEN1CYP2C19SPHK1LMNA | |
| SCHEMBL28123466 | 0.71 | SPHK1 (0.45) | NPC1RAB9AHPGDTP53SMN1; SMN2 | |
| SCHEMBL19633181 | 0.71 | TAAR1 (0.48) | ALDH1A1MAPTGAALMNA | |
| SCHEMBL7936552 | 0.69 | HPGD (0.50) | NPC1RAB9AHPGDSMN1; SMN2KMT2A | |
| SCHEMBL10612231 | 0.69 | SPHK1 (0.44) | TP53KDM4EALDH1A1SPHK1LMNA | |
| SCHEMBL10612237 | 0.69 | SPHK1 (0.44) | TP53KDM4EALDH1A1SPHK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370420-B9 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-11-13 | — | — | EP | disclosed |
| EP-2370420-B1 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-05-22 | — | — | EP | disclosed |
| EP-2357217-B9 | PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2019-03-13 | — | — | EP | disclosed |
| US-10005763-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-10000472-B2 | Photochromic compounds | TRANSITIONS OPTICAL, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| EP-2651913-B1 | INDENO-FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | TRANSITIONS OPTICAL INC (US) | 2017-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005763-B2 | Photochromic compounds | CCR4, CCR8, CBR3 | NPC1 2905/4885RAB9A 2043/4885HPGD 2895/4885 |
| US-10000472-B2 | Photochromic compounds | CCR4, CCR8, CBR3 | NPC1 2905/4885RAB9A 2043/4885HPGD 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.