Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24451810 | 0.83 | MAPT (0.50) | TAAR1MAPTSIGMAR1PLK1GAA | |
| SCHEMBL3060595 | 0.81 | TAAR1 (0.64) | TAAR1MAPTTMEM97SIGMAR1PLK1 | |
| SCHEMBL12895818 | 0.81 | ADRA2A (0.50) | MAPTPLK1GAAALDH1A1LMNA | |
| SCHEMBL24324959 | 0.80 | SPHK1 (0.47) | MAPTSIGMAR1GAAALDH1A1LMNA | |
| SCHEMBL11454956 | 0.80 | LMNA (0.49) | MAPTPLK1GAAALDH1A1LMNA | |
| SCHEMBL11935542 | 0.78 | HTR2A (0.46) | MAPT | |
| SCHEMBL11934948 | 0.78 | SIGMAR1 (0.53) | TAAR1MAPTSIGMAR1PLK1GAA | |
| SCHEMBL19203843 | 0.78 | MAPT (0.46) | TAAR1MAPTTMEM97SIGMAR1GAA | |
| SCHEMBL12452414 | 0.76 | PLK1 (0.50) | PLK1GAAALDH1A1LMNATDP1 | |
| SCHEMBL10888982 | 0.76 | BCHE (0.44) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197488-A1 | LIBRARIES OF DIVERSE MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | CYCLENIUM PHARMA INC. (CA) | 2017-11-23 | — | — | WO | disclosed |