Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16657375 | 0.86 | ALDH1A1 (0.70) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL4379830 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16634745 | 0.84 | ALDH1A1 (0.54) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16634742 | 0.84 | ALDH1A1 (0.54) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16657400 | 0.81 | HTT (0.67) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL9335042 | 0.79 | ALDH1A1 (0.74) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL9849856 | 0.77 | ALDH1A1 (0.70) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL985886 | 0.76 | ALDH1A1 (0.63) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16067604 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL27987003 | 0.74 | ALDH1A1 (0.78) | ALDH1A1HTTRAB9AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864323-B1 | 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH HETEROCYCLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-04-19 | — | — | EP | disclosed |