Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16657375 | 0.86 | ALDH1A1 (0.70) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL18754336 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16634745 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16634742 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16657400 | 0.81 | HTT (0.67) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL28073238 | 0.81 | MAPK1 (0.51) | ALDH1A1RAB9AMAPTGAAMAP2K1 | |
| SCHEMBL16067604 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL985886 | 0.76 | ALDH1A1 (0.63) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL16657372 | 0.75 | ALDH1A1 (0.82) | ALDH1A1HTTRAB9AMAPTGAA | |
| SCHEMBL24539455 | 0.75 | MAP2K1 (0.56) | MAP2K1MAP2K2PRKCZIARS2NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012786-A2 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | Ardea Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007121481-A2 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2007-10-25 | — | — | WO | disclosed |