SCHEMBL18754697

SCHEMBL18754697

Cc1cn(-c2ccc(F)cc2)cn1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP19A1 P11511 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
CYP2E1 P05181 1/20 0.51
CYP2A6 P11509 1/20 0.51
PDE4A P27815 1/20 0.47
PDE4B Q07343 1/20 0.47
PDE4C Q08493 1/20 0.47
PDE4D Q08499 1/20 0.47
PSEN1 P49768 10/20 0.45
PSEN2 P49810 10/20 0.45
APH1B Q8WW43 10/20 0.45
NCSTN Q92542 10/20 0.45
APH1A Q96BI3 10/20 0.45
PSENEN Q9NZ42 10/20 0.45
NR2E1 Q9Y466 1/20 0.45
KCNH2 Q12809 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27985278 0.89 CYP1A2 (0.65) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL1845259 0.84 POLB (0.51) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL2285981 0.83 CYP1A2 (0.59) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL12988609 0.80 CYP3A4 (0.56) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL4668245 0.80 CYP1A2 (0.56) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL264998 0.80 CYP1A2 (0.56) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL19272800 0.80 CYP1A2 (0.56) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL4666728 0.80 CYP3A4 (0.56) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL22198914 0.79 NR2E1 (0.60) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9
SCHEMBL2283022 0.79 CYP2E1 (0.65) CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022007966-A1 PB2 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 四川海思科制药有限公司 2022-01-13 WO disclosed
WO-2021126729-A1 PRMT5 INHIBITORS MERCK SHARP & DOHME CORP. (US) 2021-06-24 WO disclosed
CN-107849042-A Bicyclic heterocycle derivatives 默克专利股份公司 2018-03-27 CN disclosed
WO-2017140758-A1 DERIVATIVES OF 2-AMINO-4-(2-OXAZOLIDINON-3-YL)-PYRIMIDINE FUSED WITH A FIVE-MEMBERED HETEROAROMATIC RING IN 5,6-POSITION WHICH ARE USEFUL FOR THE TREATMENT OF VARIOUS CANCERS DEBIOPHARM INTERNATIONAL S.A. (CH) 2017-08-24 WO disclosed
EP-2534170-B1 IAP BIR DOMAIN BINDING COMPOUNDS PHARMASCIENCE INC (CA) 2017-04-19 EP disclosed