Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.57 |
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 10/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | GLA | P06280 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570407 | 0.81 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL10162406 | 0.80 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL2335762 | 0.80 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL1901476 | 0.80 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL10130703 | 0.76 | KDM4E (0.59) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL12200399 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL1407731 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL7305755 | 0.73 | KDM4E (0.52) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL3157196 | 0.69 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL10545241 | 0.68 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534170-B1 | IAP BIR DOMAIN BINDING COMPOUNDS | PHARMASCIENCE INC (CA) | 2017-04-19 | — | — | EP | disclosed |