Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | ACVR2A | P27037 | 4/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18653342 | 0.87 | CNR1 (0.41) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL18755256 | 0.80 | LOX (0.45) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL30626327 | 0.74 | LOX (0.55) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL16116782 | 0.74 | LOX (0.55) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL30531656 | 0.74 | LRRK2 (0.44) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL23063240 | 0.71 | LOX (0.42) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL25508475 | 0.71 | S1PR1 (0.39) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL18471249 | 0.70 | S1PR1 (0.46) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL18481804 | 0.70 | LOX (0.47) | S1PR1LOXLOXL2LRRK2ACVR2A | |
| SCHEMBL13036116 | 0.70 | DYRK1A (0.55) | S1PR1LOXLOXL2LRRK2ACVR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964633-B1 | ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-04-19 | — | — | EP | disclosed |