Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | ACVR2A | P27037 | 3/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16013957 | 0.85 | ADORA2B (0.46) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL23063240 | 0.81 | LOX (0.42) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL18755228 | 0.80 | S1PR1 (0.40) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL20119880 | 0.78 | CYP3A4 (0.48) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL30626327 | 0.78 | LOX (0.55) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL16116782 | 0.78 | LOX (0.55) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL30531656 | 0.78 | LRRK2 (0.44) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL23674489 | 0.77 | LOX (0.37) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL18481804 | 0.77 | LOX (0.47) | LOXLOXL2S1PR1LRRK2ACVR2A | |
| SCHEMBL18755203 | 0.77 | CYP2A6 (0.50) | LOXL2ADORA2BPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964633-B1 | ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-04-19 | — | — | EP | disclosed |