Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | FES | P07332 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785035 | 0.85 | SMN1; SMN2 (0.48) | VNN1SMN1; SMN2L3MBTL1HDAC3HDAC1 | |
| SCHEMBL18756982 | 0.83 | VNN1 (0.40) | VNN1SMN1; SMN2L3MBTL1HDAC3HDAC1 | |
| SCHEMBL255574 | 0.82 | FES (0.68) | SMN1; SMN2L3MBTL1TSHRFESRET | |
| SCHEMBL18757095 | 0.80 | AOC3 (0.47) | EPHX2PRMT6NAMPT | |
| SCHEMBL12523907 | 0.78 | SMN1; SMN2 (0.43) | VNN1SMN1; SMN2L3MBTL1HDAC3HDAC1 | |
| SCHEMBL18757069 | 0.77 | VNN1 (0.44) | VNN1SMN1; SMN2HDAC1NPC1 | |
| SCHEMBL18757160 | 0.77 | CARM1 (0.39) | PRMT6 | |
| SCHEMBL18757037 | 0.75 | MAPK1 (0.39) | LMNA | |
| SCHEMBL14365887 | 0.75 | AOC3 (0.63) | SMN1; SMN2EPHX2PRMT6LMNA | |
| SCHEMBL17656758 | 0.74 | AOC3 (0.40) | VNN1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002278-B1 | GUANIDINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-04-19 | — | — | EP | disclosed |